With the growing trend of digitalization, remote work has become a new norm. This study aims to investigate whether, how, and when work-family enrichment affects innovative behavior for dual-earner couples in a work-from-home context. Based on the data of 214 telecommuting dual-earner couples, we empirically examine the relationship between bidirectional work-family enrichment and innovative behavior mediated by family affective commitment. The results indicated that in a work-from-home context, employees’ innovative behavior depends on their work-to-family enrichment. Specifically, employees’ work-to-family enrichment increased spouses’ family affective commitment, which in turn, promoted employees’ family-to-work enrichment, thereby increasing employees’ innovative behavior. The results further showed that such a transmission process is asymmetrical and contingent on spouses’ gender role perceptions. This study contributes to the literature on remote work and innovative behavior.