This study examines how family responsibility influence resource allocation and economic performance of immigrant entrepreneurs. Building on family embeddedness perspective and family-business interface literature, we investigate how immigrant entrepreneurs are motivated and constrained by family-business interdependence, and the subsequent implications to their business success. We analyzed data from a survey of 334 immigrant entrepreneurs across Spain, Italy, France, and the UK. Our findings suggest that a higher level of family responsibility is associated with a decline in venture performance. However, the negative effects of home country family dependence diminish as family dependence in host countries increases. The findings have implications for research on family embeddedness and immigrant entrepreneurship literature.