Happiness is the most cherished desire of people of all times. The pursuit of happiness has a long history grounded in ancient scriptures, traditional wisdom, contemplative practices, philosophy and positive psychology. The paper endeavors to delve deep into Eastern and Western spiritual perspectives with a view to extract insights for developing an understanding about its nature and complexities and synthesize these perspectives for a renewed understanding of holistic well-being for sustained happiness with triple bottom-line. It provides empirical evidence of a spiritual intervention (A??anga yoga) on well-being and offers directions for future research.